Massachusetts General Hospital

To date, Brian’s Fund has granted over $2,000,000 to the Brian D. Silber Memorial Fund at Massachusetts General Hospital.

Brian’s Fund has been critical in establishing and supporting the Brian D. Silber Spine Tumor Clinic at MGH. This multidisciplinary clinic offers comprehensive evaluation and treatment options for patients with spinal tumors, conducts innovative research on the causes and treatments of spinal tumors, and provides far-reaching education through lectures and laboratory work.

By providing seed money for early-stage research projects, Brian’s Fund has enabled these projects to take place, has led to increased funding based on the initial findings, and has made possible several important scientific advances. In effect, seed money saves lives!

Brian’s radiation oncologist, Dr. Jay Loeffler, and Dr. William Curry oversee the spending of money that Brian’s Fund grants to MGH.

Below are some of the ACCOMPLISHMENTS that have been made at Massachusetts General Hospital due to the generosity of Brian’s Fund:


Establishment and operation of the Brian D. Silber Spine Tumor Clinic at MGH


Expansion of MGH’s Pediatric Neurosurgery service to include special expertise in the management of spinal cord tumors in children

Rapid expansion of specialized, image-guided photon therapy for spinal tumors

Purchase of an AGFA Imaging Center for viewing spinal images and a Digitimer Cortical Stimulator for monitoring during spinal surgery

Completion of a clinical study on the long-term outcome of spinal cord tumor patients treated by radiation, “Long-Term Outcomes of Patients With Spinal Cord Gliomas Treated by Modern Conformal Radiation Techniques


Establishment of a named laboratory in memory of Brian D. Silber at MGH

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Research on spinal cord astrocytoma genomics by Dr. Ganesh Shankar, Clinical Fellow in Neurosurgery, MGH (2014-present)

January 2016 publication of research led by Dr. Ganesh Shankar, “BRAF Alteration Status and the Histone H3F3A Gene K27M Mutation Segregate Spinal Cord Astrocytoma Histology.”  These findings will hopefully lead to more precise diagnoses and effective, targeted treatments for spinal cord astrocytoma patients.

Research on spinal tumors in the laboratory of Dr. Scott Plotkin, Director, Neurofibromatosis Clinic, MGH (2009-2011).  “The best feeling in the world/Study improves hearing in NF2 patients.

Research on astrocytomas in the laboratory of Dr. Arnab Chakravarti, Director, Molecular and Cellular Radiation Neuro-Oncology Laboratory, MGH (2002-2009).  Sample publications: “A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis” & “The Prognostic Significance of Phophatidylinositol 3-Kinase Pathway Activation in Human Gliomas


Fifteen Brian D. Silber Lectureships have been held in the historic Ether Dome at MGH. Each year a clinician or researcher in the field of spinal tumors is invited to MGH to present his/her work and meet with MGH faculty. The Lectureship is a valuable way for faculty members at MGH to collaborate, learn, and share their work with other experts in the field of spinal tumors and cancer.

The Silber Lectures have featured Drs. Fred Epstein, Darell Bigner, Michael C. V. Jensen, Roy Patchell, J. Gregory Cairncross, Mark Bilsky, Antonino Raco, Paul McCormick, Kenneth Aldape, Peter Gerszten, Donald M. McDonald, Laurence Rhines, George Jallo, Viviane Tabar, Claudio Tatsui, and Lawrence Borges.

2014 Silber Lecture (2) 2015 silber lecture (2)

The First Brian D. Silber Spine Oncology Symposium, a 2-day educational exchange featuring faculty lectures and laboratory work on advanced surgical techniques for spinal tumors, was held at MGH in April 2014.

Brian D. Silber Memorial Fund

18 Heath Rd. | Peabody, MA 01960 | 978-535-4788
a 501(c)3 charity organization, Tax ID #04-3438653

© 2016 Brian D. Silber Memorial Fund

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